Genetic Report
ABOUT THIS TEST: PeyroniesGene is a proprietary genetic test that evaluates genes associated with Peyronie’s disease. This information can help patients learn associations of their genetic findings with various aspects of Peyronie’s disease.
Peyronie’s Disease Score:
The Peyronie’s disease score was created based on a combined dataset of men who were confirmed to have Peyronie’s disease versus those who did not have any symptoms of the condition. Genetic factors were then analyzed, and the likelihood of various genetic findings being correlated with Peyronie’s disease were combined to create a scoring system. Importantly, this test is not able to definitively determine if you have Peyronie’s disease or will develop it at some point in your lifetime. It is only able to tell you how your risks compare to men with different genetic results. The specific cause of Peyronie’s disease remains unknown at the present time, and it is also unclear how much of the condition is due to underlying genetics versus other lifestyle or environmental factors.
Xiaflex Predictor Score:
Similar to the Peyronie’s Disease Score, the Xiaflex Predictor Score was created based on a dataset of men who had confirmed Peyronie’s disease and had undergone Xiaflex treatment for their condition. All men had at least 30° of penile curvature at the time of treatment. Genetic factors from these men were then analyzed, and the likelihood of various genetic findings being correlated with better or worse curvature improvements with Xiaflex were then calculated to create a specific scoring system. Results reflect the likelihood of experiencing curvature improvements with treatment with Xiaflex.
Trauma-associated Curve:
Among men with penile curvature, genetic findings were correlated with the likelihood of reporting trauma as a precipitating factor leading to curvature and/or penile deformity. There is currently not enough data to know for sure if the cause for curvature or deformity is solely related to trauma (i.e., trauma-induced curvature compared to PD-curvature) or if there is also a contributing genetic component.
Hourglass / Indentation:
Findings of hourglass for indentation deformities were evaluated in men with Peyronie’s disease. Genetic results demonstrated either a higher or lower predispositions for having these conditions. These results are of unclear significance in men without Peyronie’s disease.
Erectile Function:
Correlations with erectile function were observed in men with Peyronie’s disease. Several specific questions relating to erectile function were correlated including subjective reporting of reduced erections, improved erectile function during the nocturnal hour compared to with a partner, as well as others. These results are of unclear significance in men without Peyronie’s disease.
Libido:
Findings of hourglass for indentation deformities were evaluated in men with Peyronie’s disease. Genetic results demonstrated either a higher or lower predispositions for having these conditions. These results are of unclear significance in men without Peyronie’s disease.
Risk Comparison Tables
HOW TO INTERPRET: To evaluate how your score compares to others, select the row that corresponds with your findings. You can then compare against men who have different scores. For example, if your Peyronie’s Disease Score is 2, that would mean that your risk of having Peyronie’s disease is estimated to be 3.5x lower compared to someone with a score of 5.
Further Information
Individuals who would like to review their PeyroniesGene report are encouraged to discuss the findings with their ordering provider. Clinicians with questions may contact
clinicians@peyroniesgene.com.